Genome Annotation

1999/9/8


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目錄

Genome Annotation

Information Biology vs Bioinformatics

The Nature of Genome Analysis

The Need for Automatic Analysis

The Need for Value-Added Databases

Lots of Functionally Unknown Sequences in GenBank

Expressed Sequence Tag (EST)

Gold Mining in A Field Full of Fool’s Gold

Why is there an incorrect assignment?

Tigger1 Was Discovered on 1996

Assignment Was Made in 1997

Transitive Catastrophy

Rate-limiting Step of Genome Analysis

The Differences between Analyzing cDNA and Genomic sequence

Gene Finding Tools

Effect of Frameshift Mutation on Gene Finding

Detection of Frameshift Mutation

Gene Modeling

Genotator: An Integrated Analysis in Graphics

Types of Analyses in Genotator

Assign the 3’ End of A Gene

EST That Has Poly(A) Signal or?Poly(A) Tail Can Define the?3’-End of A Gene

Assign the 5’ End of A Gene

Different Exons Will Match with Identical Polypeptide (I)

Different Exons Will Match with Identical Polypeptide (II)

Different Exons Will Match with Identical Polypeptide (III)

Browse the Blast Results

Assign the Splicing Junctions of A Gene

Rationale (I)

Rationale (II)

An Example of Splicing Junction Prediction

Tissue Distribution of p97-related mRNA

Whether EST is sufficient for gene finding / modeling?

Rapidly Growing EST Information Favors in silico Approach

Acknowledgements

作者:yang

電子郵件: yang@ym.edu.tw

首頁: http://biochem.ym.edu.tw/binfo/

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