Gene families, domains, motifs, and sites
Tree of life
Although phenotype could be determined by a pathway, only a few factors may play regulatory roles in expression.
Resolution of measuring devices
How was gene families derived?
Similar proteins share common structures
Homology vs similarity
Accepted Point Mutation (PAM)
Blocks and blosum matrix
The whole pathway can also be duplicated
Domains and motifs are independent folding unit
TFIIIA has multiple repeats
Zinc finger motifs - repeats in the same protein
Sequence Databank Searching Tools in GCG
Orthologous vs paralogous
Cluster of Orthologous Group
Why do we need to define protein families in genome annotation?
How to define protein families?