Problem-Oriented Learning (III): Analysis of Zinc-Finger Motifs

1999/8/3


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目錄

Problem-Oriented Learning (III): Analysis of Zinc-Finger Motifs

Concepts

The Language Analogy of Sequence Information

How to look for words?

The discovery of zinc finger

Diagonal Matrix?Method

Scoring System

Demo 7-1

Comparison => Look for Homology (Repeats)

Compare and DotPlot

Demo 7-2

Discussion

Window

Stringency

Meaning of a dot plot

Effect of window size (I)

Effect of window size (II)

Effect of strigency

How to read a dot matrix plot?

Potential Repeats in TFIIIA

Ex. 7-1

Answers to Ex 7-1

Local Sequence Alignment

Proposed Structure of A Zinc Finger by MRC Group

Effect of models on proposed interaction mechanisms

Demo 7-3

Convention to Express Patterns

Berg’s Zinc-Finger Pattern

Ex. 7-2

Multiple Sequence Alignment

Answer to Ex. 7-2

Sequence Databank Searching Tools in GCG

Pattern Search

Demo 7-4

Answer to Demo 7-4

Discussion

Demo 7-5

Answer to Demo 7-5

Ex. 7-3

Two Types of Zinc-Finger Pattern

Answer to Ex. 7-3

Structure of C-X2-C

Structure of H-X3-H

Model Building Based on Homology

Structure Homology

The Three Dimensional Structure of A Zinc-Finger

Conclusion

作者:楊永正

首頁: http://biochem.ym.edu.tw/binfo/

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