The two papers attached may give you considerable idea about SVM and its application in expression analysis, which wasn't clarified by Lin .
Jung-Wei Fan
>Support Vector Machines
>in Computational Biology
>Support Vector Machines have a natural
>match with the features of many bioinformatics
>datasets. They deliver state of the art performance in several application,
and for microarray gene expression data, are becoming the system of choice. Here
is a list of publications...
>
> Gene Function from microarray expression data
>
>Knowledge-based analysis of microarray gene expression data by using support
vector machines, Michael P. S. Brown, William Noble Grundy, David Lin, Nello
Cristianini, Charles Walsh Sugnet, Terence S. Furey, Manuel Ares, Jr., David
Haussler, Proc. Natl. Acad. Sci. USA, vol. 97, pages 262-267
>pdf
>http://www.pnas.org/cgi/reprint/97/1/262.pdf
>
>Support Vector Machine Classification of Microarray Gene Expression Data,
Michael P. S. Brown William Noble Grundy, David Lin, Nello Cristianini, Charles
Sugnet, Manuel Ares, Jr., David Haussler
>ps.gz
>http://www.cse.ucsc.edu/research/compbio/genex/genex.ps
>
>Gene functional classification from heterogeneous data Paul Pavlidis, Jason
Weston, Jinsong Cai and William Noble Grundy, Proceedings of RECOMB 2001
>pdf
>http://www.cs.columbia.edu/compbio/exp-phylo/exp-phylo.pdf
>
>Cancer Tissue classification
>from microarray expression data, and gene selection:
>
>Support vector machine classification of microarray data, S. Mukherjee, P.
Tamayo, J.P. Mesirov, D. Slonim, A. Verri, and T. Poggio, Technical Report 182,
AI Memo 1676, CBCL, 1999.
>ps.gz
>PS file here
>
>Support Vector Machine Classification and Validation of Cancer Tissue
Samples Using Microarray Expression Data, Terrence S. Furey, Nigel Duffy, Nello
Cristianini, David Bednarski, Michel Schummer, and David Haussler,
Bioinformatics. 2000, 16(10):906-914.
>pdf
>http://bioinformatics.oupjournals.org/cgi/reprint/16/10/906.pdf
>
>Gene Selection for Cancer Classification using Support Vector Machines, I.
Guyon, J. Weston, S. Barnhill and V. Vapnik, Machine Learning 46(1/3): 389-422,
January 2002
>pdf
>http://homepages.nyu.edu/~jaw281/genesel.pdf
>
>Molecular classification of multiple tumor types ( C. Yeang, S. Ramaswamy,
P. Tamayo, Sayan Mukerjee, R. Rifkin, M Angelo, M. Reich, E. Lander, J. Mesirov,
and T. Golub) Intelligent Systems in Molecular Biology
>Combining HMM and SVM : the Fisher Kernel
>
>Exploiting generative models in discriminative classifiers, T. Jaakkola and
D. Haussler, Preprint, Dept. of Computer Science, Univ. of California, 1998
>ps.gz
>http://www.cse.ucsc.edu/research/ml/papers/Jaakola.ps
>
>A discrimitive framework for detecting remote protein homologies, T.
Jaakkola, M. Diekhans, and D. Haussler, Journal of Computational Biology, Vol. 7
No. 1,2 pp. 95-114, (2000)
>ps.gz
>PS file here
>
>Classifying G-Protein Coupled Receptors with Support Vector Machines, Rachel
Karchin, Master's Thesis, June 2000
>ps.gz
>PSgz here
>
>The Fisher Kernel for classification of genes
>
>Promoter region-based classification of genes, Paul Pavlidis, Terrence S.
Furey, Muriel Liberto, David Haussler and William Noble Grundy, Proceedings of
the Pacific Symposium on Biocomputing, January 3-7, 2001. pp. 151-163.
>pdf
>http://www.cs.columbia.edu/~bgrundy/papers/prom-svm.pdf
>
>String Matching Kernels
>
>David Haussler: "Convolution kernels on discrete structures"
>ps.gz
>Chris Watkins: "Dynamic alignment kernels"
>ps.gz
>J.-P. Vert; "Support vector machine prediction of signal peptide
cleavage site using a new class of kernels for strings"
>pdf
>
>Translation initiation site recognition in DNA
>
>Engineering support vector machine kernels that recognize translation
initiation sites, A. Zien, G. Ratsch, S. Mika, B. Scholkopf, T. Lengauer, and
K.-R. Muller, BioInformatics, 16(9):799-807, 2000.
>pdf.gz
>http://bioinformatics.oupjournals.org/cgi/reprint/16/9/799.pdf
>
>Protein fold recognition
>
>Multi-class protein fold recognition using support vector machines and
neural networks, Chris Ding and Inna Dubchak, Bioinformatics, 17:349-358, 2001
>ps.gz
>http://www.kernel-machines.org/papers/upload_4192_bioinfo.ps
>
>Support Vector Machines for predicting protein structural class Yu-Dong Cai*1
, Xiao-Jun Liu 2 , Xue-biao Xu 3 and Guo-Ping Zhou 4
>BMC Bioinformatics (2001) 2:3
>http://www.biomedcentral.com/content/pdf/1471-2105-2-3.pdf
>
>The spectrum kernel: A string kernel for SVM protein classification
Christina Leslie, Eleazar Eskin and William Stafford Noble Proceedings of the
Pacific Symposium on Biocomputing, 2002
>http://www.cs.columbia.edu/~bgrundy/papers/spectrum.html
>
>
>
>Protein-protein interactions
>
>Predicting protein-protein interactions from primary structure w, Joel R.
Bock and David A. Gough, Bioinformatics 2001 17: 455-460
>pdf
>http://bioinformatics.oupjournals.org/cgi/reprint/17/5/455.pdf
>
>Protein secondary structure prediction
>
>A Novel Method of Protein Secondary Structure Prediction with High Segment
Overlap Measure: Support Vector Machine Approach, Sujun Hua and Zhirong Sun,
Journal of Molecular Biology, vol. 308 n.2, pages 397-407, April 2001.
>
>Protein Localization
>
>
>Sujun Hua and Zhirong Sun Support vector machine approach for protein
subcellular localization prediction Bioinformatics 2001 17: 721-728