The cytoplasmic body component TRIM5a restricts HIV-1 infection in Old World monkeys

2004/9/16

生資所碩一 謝威翔

 

Abstract:

HIV-1 can cause the acquired immunodeficiency syndrome in human and SIV naturally infects Old World monkey. 

HIV-1-GFP is one kind of recombinant HIV-1 which expresses green fluorescent protein. Using HIV-1-GFP infection and the insert 

of Old World monkey cDNA library Hela cell, the authors found some clones can resist the HIV-1 infection. They identify the TRIM5

which blocks HIV-1 reverse transcription. But SIV is less susceptible to TRIM5 affection. Knowing the species-specific restrictions to 

HIV-1 infection may provide new approaches to prevent the acquired immunodeficiency syndrome in human.

 

Author: Stremlau M, Owens CM, Perron MJ, Kiessling M, Autissier P, Sodroski J.

Source: Nature. 2004 Feb 26;427(6977):791-3.

 

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