Translation initiation
with 70S ribosomes: an alternative pathway for
leaderless mRNAs
生資所碩一 曾詩軒
Abstract:
In this paper, we want to demonstrate the proficiency of dedicated 70S ribosomes in in vitro translation
of leaderless mRNAs. SO our study show that a natural
leaderless mRNA can be translated with crosslinked
70S wild-type ribosomes. Besides, leaderless mRNA
translation continues under conditions where the prevalence of 70S ribosomes is created in vivo, and where translation of bulk
mRNA ceases.
Author: Isabella Moll*, Go Hirokawa1, Michael C. Kiel1, Akira Kaji1 and Udo Bla¨si
Source: Nucleic
Acids Res. 2004 Jun 23;32(11):3354-63. Print 2004.
Reference:
1. Kozak,M. (1999) Initiation of
translation in prokaryotes and eukaryotes.Gene, 234,
187–208.
2. Moll,