生資所
39008006 陳琦
Abstract:
About 8 percent of genes in yeast S. cerevisiae shows duplication blocks, but their origin is still controversial. By sequencing and analysing Kluyveromyces waltii, a related yeast species that diverged before the duplication, they show that the synteny of each region ofK. waltii can map to 2 regions of S. cerevisiae, as a direct evidence showing ancestral whole-genome duplication. Moreover, by comparing duplicated gene pairs with homologs in K. waltii they show that gene pairs involving accelerated evolution usually only accelerate one of the paired genes in either proteinor nucleotide level, as a support of a specific evolutionary model that one of the duplicated genes would be free to diverge while another one would preserve the original function.
Source:
Nature. 2004 Apr 8;428(6983):617-24.
Reference:
Wolfe, K. H. & Shields, D. C. Molecular evidence for an ancient duplication of the entire yeast genome. Nature 387, 708–713 (1997)
Piskur, J. Origin of the duplicated regions in the yeast genomes. Trends Genet. 17, 302–303 (2001)
Friedman, R. & Hughes, A. L. Gene duplication and the structure of eukaryotic genomes. Genome Res. 11, 373–381 (2001)