A Protein Interaction Map of Drosophila melanogaster.
生化所生資學程
39203001 甘瑞麒
Abstract:
Research of protein-protein interaction is important for figuring out the functions of proteins. Giot et al. used large-scale yeast two-hybrid method to build a draft protein interaction map of Drosophila melanogaster. They used computational statistic method to refine the map to produce a high confidence map. The statistical analysis showed that protein interaction network is a small-world network which may represent local proteins complex connections and global inter-complex connections.
Source:
Giot L (2003) A Protein Interaction Map of Drosophila melanogaster. Science, 302:1727-36.
Reference:
Uetz P et al. (2000) A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature, 403: 623-627.
Watts DJ, Strogatz SH. (1998) Collective dynamics of 'small-world' networks. Nature. 393:440-2.