Genomic Gene Clustering Analysis of Pathways in Eukaryotes

Author¡GJennifer M. Lee, and Erik L.L. Sonnhammer

Hon-Wei Chen, Mar.30,2004

Abstract¡G

Genomic clustering of genes in a pathway is commonly found in prokaryotes due to transcriptional operons,
but these are not present in most eukaryotes .the Paper analyzed five sequenced eukaryotic genomes called
"Saccharomyces cerevisiae, Homo sapiens, Caenorhabditis elegans, Arabidopsis thaliana, and Drosophila melanogaster"
for clustering of genes assigned to the same pathway in the KEGG database.
Surprisingly, there seems between genomes in terms of which pathways are most clustered.
Only seven of 69 pathways found in all species were significantly clustered in all five of them.

Source¡G

Published in Genome Research, vol. 13, no. 5, pp. 875-882 (May, 2003).
Published online before print April 14, 2003, 10.1101/gr.737703
http://www.genome.org/cgi/content/abstract/13/5/875?etoc

Reference:

1. SNAPping up Functionally Related Genes Based on Context Information: A Colinearity-free Approach . J.Mol.Biol.311:639-656

2. The use of gene clusters to infer functional coupling.Proc. Natl.Acad. Sci. 96:2896-2901

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