A conserved protein interaction network involving the yeast MAP kinases Fus3 and Kss1

A conserved protein interaction network involving the yeast MAP kinases Fus3 and Kss1

April 13, 2004

Cheng-Wei Cheng

Abstract

The mitogen-activated protein kinases (MAPKs) play important roles in Saccharomyces cerevisiae because they can respond the change of environment and have proper regulation, like inducing mating, filamentousinvasive growth and so on by interact with the substrates and regulators. At the same time, they find a conserved docking site of MAPKs influences this mechanism a lot. When MAPKs have mutation in the docking site, it will disrupt the binding of MAPKs with its important partners. On the other hand, they found this mutation indeed has effect on mating and pheromone response in vivo. Therefore, the docking site in MAPKs does have the key step to affect yeast. In addition, this feature also conserved in human.

From：The Journal of Cell Biology, Vol 164, Number 2, 267-277, January 19, 2004

Reference

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