The effect of oxidative stress on accumulation of apolipoprotein E3 and E4 in a cell culture model of b-amyloid angiopathy (CAA)

Y.C.Fang

Abstract：

Apolipoprotein E (apoE) is a multifunctional molecule. It is active during brain development, maintenance, and injury. Allele ε4 of apoE is recognized as a risk factor for β-amyloidosis, but the responsible mechanisms are not clear. The presence of the ε4 allele of apoE is a risk factor for development of Alzheimer’s disease (AD). In AD brain, greater oxidative damage was associated with the presence of the ε4 allele. Recently, the authors showed that brain vascular smooth muscle cells (SMCs) from ε4/ε4 carriers are the most susceptible to oxidative protein damage that was associated with the appearance of apoE-Ab-immunoreactive granules in cells. Here, they demonstrate that apoE4 is more readily accumulated in SMCs treated with ferrous ions than is apoE3. The higher cellular accumulation of apoE4 than apoE3 in SMCs exposed to oxidative stress may facilitate development of β-amyloid angiopathy that is more frequent in ε4/ε4 carriers.

From：

Bozena Mazur-Kolecka , Dagmar Kowal , Tirasak Sukontasup , Dennis Dickson , Janusz Frackowiak

Brain Research

Volume 983, Issues 1-2 , 5 September 2003 , Pages 48-57

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