Single nucleotide polymorphism identification in candidate gene systems of obesity

 

November 11, 2003

郭啟沐

 

Abstract

        Single Nucleotide polymorphisms (SNPs) are the most common genetic variations and occur once every 100 to 300 bases. Recently, SNPs have been used as a high resolution marker set to accelerate the identification of disease genes. This paper used Bayesian inference to weigh evidence for true polymorphism versus sequencing error to create a model, and used statistical scoring of candidate SNPs to identify the SNPs in obesity candidate genes. 

   

From：The Pharmacogenomics Joural (2001) 1,193-203

 

Reference

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2.      Modrek, B., Resch, A., Grasso, C., Lee, C. (2001) Genome-wide detection of alternative splicing in expressed sequences of human genes. Nucleic Acids Research 29: 2850-2859.

3.      Kimball's Biology Pages http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/