Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes.

2003/12/23

甘瑞麒

Abstract:

Genomic comparison between two organisms can guide further study to understand gene function and evolution history. S. Aparicio et al. use whole genome shotgun approach to sequence the genome of Fugu rubripes. Initial comparison of fugu and human shows that fugu has less than 38,000 genes and about 1,000 novel putative human gene is discovered. An estimated 25% of human proteome cannot be found in fugu represent the divergence of evolution between two organisms. The Fugu genome project also shows that sequence comes from whole genome shotgun approach without mapping information is a cheaper, more efficient way for further genomic analysis.

Source:

Aparicio, S., Chapman, J., Stupka, E., Putnam, N., Chia, J.M., Dehal, P., Christoffels, A., Rash, S., Hoon, S., Smit, A.F. (2002). Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes. Science 297: 1301-1310

http://www.sciencemag.org/cgi/content/abstract/297/5585/1301

Reference:

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