Bioinformatics study of Spinocerebellar Ataxia genes

2000/6/18


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目錄

Bioinformatics study of Spinocerebellar Ataxia genes

Human genome project

Progress of human genome sequencing

Positional candidate gene approach

Any fool can find a problem that he can solve

第22號染色體上之重複序列

Current status of SCA studies

Basic information

Strategy

Testing the validity of this approach

There are 660 STS markers in 3p21.1-p12

There are 102 HTG sequences in 3p21.1-p12

Gene annotation reveals the relation among repeats and genes

Extent of annotation

There are 3 candidate genes in 3p21.1-p12

Summary

Map information for other SCA genes

Identification of candidate genes

More examples

More examples (continued)

Identification of candidate genes

Candidate gene discovery - Using in silico chromosome jumping

Summary => genome wide scanning?

SCA7 cDNA - HTGS alignment

Other applications of this technique

Collaborators

作者:yang

電子郵件: yang@ym.edu.tw

首頁: http://binfo.ym.edu.tw/yang/

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